I'll release a full run guide soon, however in the meantime you can use this: Notes: All damage roles assume worst stats possible for your Mewtwo. If your defense is high, for example, you'll take way less damage than listed here Do a slightly altered Any% route, you can find a guide here: https://www.speedrun.com/pkmnletsgo/guides Add the following things into the route: Pokemon Aerodactyl - You may as well get Omanyte/Kabuto as well for Pokemon count purposes, but it's not required Gyarados - Catch a Magikarp on Route 21 and evolve it. Try to get it to Level 45 before depositing it Shopping Escape Rope x1 X Attack x3 X Defense x2 X Sp. Atk x12 X Sp. Def x1 X Speed x3 Full Restores xMany (max buy in Indigo Plateau) Pick Ups TM37 Flamethrower - Silph Co. 10F - After beating Giovanni, take the Elevator to 10F. Run left and down into the room and grab the left Item Ball Max Elixir - Any% usually gets an Elixir (Route 17) and Max Elixir (Mansion). Pick up the Elixir in Rocket Hideout too, and use the normal Elixirs on Starmie, leaving the Max Elixir for the postgame Other things Don't use your Master Ball --- Just beat the game 4Head Skip the cutscene after credits. After conversations outside, fly to Indigo Plateau Buy the Gyarados Mega Stone. Outside, open your menu - Withdraw Gyarados, Aerodactyl and Rapidash - Put Gyarados in slot 2 - Ride Aerodactyl - Fly to Cerulean Go to Cerulean Cave and ride Rapidash. Navigate through Cerulean Cave to Mewtwo (refresh repel). Get the PP Max in the water (all the way left and up next to Mewtwo) and then approach Mewtwo. Save and bring out 2c before talking to him. Skip the cutscene Mewtwo - X Attack Gyarados / (Mega) Bite. Do this until Mewtwo faints. Heal as needed (Swift does a little over half to Gyarados. Catch Mewtwo in the Master Ball Open your menu - Ride Aerodactyl - Deposit Gyarados and Starmie - Put Mewtwo in slot 1 - Teach Thunderbolt to Mewtwo over Amnesia - Teach Flamethrower to Mewtwo over Recover - Escape Rope Misty Golduck - Thunderbolt Vaporeon - X Sp. Atk, Thunderbolt Hydro Pump does 90 Quick Attack does 15 Gyarados - Thunderbolt Starmie - Thunderbolt Dewgong - Thunderbolt Aqua Jet does 27 Ice Shard does 27 Ride Aero, swap Full Restore to the front, heal if below 181 and fly to Celadon Erika Tangela - Flamethrower Parasect - Flamethrower Exeggutor - Flamethrower Victreebel - Flamethrower Vileplume - Psychic Ride Aero, fly to Saffron Sabrina Mr. Mime - X Sp. Atk x2, Swift, Flamethrower Dazzling Gleam does 60 If no light screen, Flamethrower on turn 3 Jynx - Flamethrower Slowbro - Thunderbolt Alakazam - Swift Hypno - Flamethrower Ride Aero, heal to full and fly to Vermilion. Ride Rapidash before entering gym Lt. Surge Electrode - X Defense, X Sp. Atk, Flamethrower Faster than Mewtwo Foul Play does 60 Jolteon - Psychic Continue setup if Electrode exploded Shadow Ball does 88 Quick Attack does 8 Magneton - Flamethrower Raichu - Flamethrower Quick Attack does 11 Electabuzz - Flamethrower Heal if below 83 and fly to Fuschia. Walk right to Koga (no walls) Koga Tentacruel - Psychic Venomoth - Psychic Golbat - Psychic *STATS* Muk - Psychic Weezing - Psychic Fly to Cinnabar. Walk onto the stage to talk to Blaine Blaine Magmar - X Sp. Atk, Psychic Fire Punch does 54 Rapidash - Psychic Quick Attack does 23 Ninetales - Psychic Quick Attack does 17 Arcanine - Psychic Flareon - Psychic Quick Attack does 28 Heal to full and fly to Viridian. Go left in the gym like Any% Blue Tauros - X Defense, X Speed, X Sp. Atk x2, Swift Use Thunderbolt if you somehow got no Double-Edge Double-Edge does 61, heal as needed Alakazam - Thunderbolt Gyarados - Thunderbolt Aerodactyl - Thunderbolt Exeggutro - Flamethrower Charizard-Y - Thunderbolt Heal if below 80 and fly to Pewter Onix - Psychic Kabutops - Thunderbolt Aqua Jet does 16 Aerodactyl - Thunderbolt Omastar - Thunderbolt Golem - Psychic (Flamethrower) Earthquake does 79 Go outside and open your menu - Heal to full - Max Elixir - Fly to Indigo Plateau Lorelei Dewgong - X Sp. Atk, Thunderbolt Waterfall does 52 Aqua Jet does 27 Ice Shard does 27 Jynx - Flamethrower Cloyster - Flamethrower Check Speed for 210 Slowbro - Thunderbolt Lapras - Thunderbolt Sandslash-A - Thunderbolt Bruno Onix - X Sp. Atk, Psychic Earthquake does 48 Poliwrath - Psychic Golem-A - Psychic Machamp - Psychic Hitmonlee - Psychic Hitmonchan - Psychic Heal to full Agatha Arbok - Psychic Gengar - Psychic Sucker Punch does 62 Golbat - Psychic Weezing - Psychic Marowak-A - Thunderbolt x2 (?) Flare Blitz does 99 Gengar - Psychic Sucker Punch does 62 Heal to full Lance Seadra - X Sp. Def, X Speed, X Sp. Atk x2, Swift Skip X Speed if 210 Speed or higher Hydro Pump does 49 Heal as needed Aerodactyl - Thunderbolt Gyarados - Thunderbolt Exeggutor-A - Flamethrower Dragonite - Psychic Check Speed for 203 Charizard-X - Psychic If less than 203 Speed, heal if below 193 Otherwise, heal if below 110 Champion Pidgeot-M - X Speed, X Sp. Atk, Thunderbolt Skip X Speed if 203 Speed or higher Usually U-Turns into Vileplume (if it does, finish setup on Vileplume) Air Slash does 84 U-Turn does 70 Quick Attack does 30 Vileplume - Flamethrower Sludge Bomb does 96 Rapidash - Psychic Slowbro - Thunderbolt Raichu - Psychic Quick Attack does 25 Marowak - Psychic