Don't manip Squirtle
Turn on Switch before the run
Get PC Potion
Flash Start before leaving Pallet Town to skip a cutscene
Don't kill anything on Route 1
Don't leave Route 1 without catching a Pidgey, can also consider grinding for one on Route 2 (higher levels on average)
Nickname your Pidgey
Get 3+ Potions before Sammy
Swap Pidgey to the front before Weedle guy and split exp
Weedle Guy: Tail Whip + Tackle spam
Don't mess around with getting Torrent, too dangerous with lower level
SKIP Liam!
Heal to full before Brock, can also consider center if poisoned and want to conserve potions
Brock: Bubble spam, split exp on both pokes
If you have two slaves, consider letting one of them dying on Onix to get a free switch in
Rock Tomb should do around half
Mart: Buy 3 Pokeballs, 6 Potions, 2 Antidotes, 1 Para Heal and 5 Repels
Switch to set
You don't need to split any more exp, just tackle the first caterpie on L2-3 pigi
BC 1: Tackle spam then Gust spam
Fight Lass over Bug Catcher
Lass: Gust spam
Leave Route 3 and come back to reset the lass's position
Last BC: Gust spam
If L4/L5 Pidgey was caught, knock Metapod fairly low, then switch to Squirtle and finish it with Bubble
You should be L12, barely not L13 after this last Bug Catcher
Get Persim Berry
Don't fight any optionals
Get Star Piece down the first staircase in Moon (high safety for Misty)
Get Rare Candy
Get Moon Stone
Get the Revive
Once you get to right in front of the rocket, if you haven't gotten an encounter yet, do turnframes until you get a Clefairy (to save repel steps)
Once you encounter the L12 Clefairy, weaken it just below half health, and then start throwing balls
Clefairy Catch Brackets: <65% = 40%, <47% = 50%, <22% = 62% (w/paras stun spore: 62%, 78%, 100%)
Once you catch the Clefairy, name it 1 character and evolve with the moon stone 
Rocket: Pound x3, Pound x3
Nerd: Swap Pound to Slot 3 + (Sing,) Pound x4, (Sing,) Pound x4, Pound x2
Leave Mt. Moon
Teach Mega Punch over Encore (Slot 1)
Teach Mega Kick over Growl (Slot 2)
Get cutter if you don't have one
Take the center
Go to mart and shop: Sell Star Piece, Buy 6 Supers, 2 Antidotes, 2 Awakenings, 3 Repels
Get the Rare Candy
Bridge Rival: MK + MP, MK (MP with decent ATK), MP, MP x2
After Bridge Rival, heal to full, equip Persim Berry before Misty, turn to switch mode
Misty: MK + MP (MP x2 if good attack), switch to Squirtle, Tail Whip + die, MK x2
Try to leave Staryu with a lot of HP
Starmie Water Pulse does just over ~1/3
Go back to set mode
Center again, teach Water Pulse over Sing (Slot 4)
During this section, finish anything that lives with pound
NB 1: WP x4
NB 2: MP/WP (if 41+ SPATK (x/30+/14+), MP x2
NB 3: WP, MK (MP if 35+ ATK at L19, x/18+/3+)
NB 4: MP, MK (MP if 39+ ATK at L20, x/30+/15+)
You can also consider WP x2 Nido F if you're worried about kick pp and you can't MP
NB 5: MP (faster at 34+ Speed x/22+/7+)
Rocket: MK (MP if 36+ Attack x/15+/0+), MP 
Get Elixir
Can also opt to fight Franklin and Flint over Wayne and Nob, changes are listed at the bottom of this route
Bottom Hiker: WP
Lass: MP, MP (MK if 34- ATK at L21)
Nob: WP, MP, WP x2
Lass 2: MP x2, WP
Get Ether if low on kicks and likely won't make it to boat, otherwise skip
Dig Rocket: MK (MP if 43+ ATK at L23), MP
Get Rare Candy
Youngster: WP (MP if 44- SPATK at L23), MK (MP if 40+ ATK at L23)
Take boat heal if low on kicks or HP
Boat Rival: MK Pidgeotto, MK Raticate, MP Kadabra, MK Ivysaur (range)
Take Boat Heal again if less than 3 kicks or pretty far from full HP
Teach Cut to cutter
Get Bike Voucher and go back to Cerulean
Get the bike
Open bag + register and use bike and bike east
Alicia: MP x4
Run to bike spinner
Bug Catcher: WP x2, MK
Get Rare Candy
Enter Rock Tunnel, Repel right away, Elixir sometime in a repel menu when you need kicks
Pokemaniac: WP + Pound, MK + MP
Pokemaniac: MK x2
Martha: MK, MK (MP if +attack)
Geodude: WP
Bottom Hiker: WP x3
Lass: MP x3 (can Pound Meowth with + Attack)
Hiker: WP x3
Lass: WP (15/16 @ 0 Neutral), MP, WP
Buy 1 Super Potion (if you have none), 4 Escape Ropes and 7 Super Repels in Lavender
Rare Candy x3 to L33
Get Return
Gambler: WP, MP
As soon as you get to Celadon, get the Tea and go west to get Fly
Bike east to Saffron
Get TM29 Psychic from the bottom right house
Go south to Vermillion
Do Cans
Teach Psychic over Mega Kick (Slot 2), Return over Mega Punch (Slot 1), Fly to flier all in a bag manip
Tucker: Psychic
Surge: Return, Psychic, Return (very good OHKO range)
Outspeed Raichu at 54+ Speed (x/23+/11+)
Fly back to Celadon
Enter Game Corner
Grunt: Return x2
Get Max Ether
Lift Key guy: Return x2
Get Lift Key
Get Rare Candy
Get Calcium
Left Guy: Psychic, WP, Return
Right Guy: Return, Psychic x2
Gio: WP, WP, Return x3
Get Silph Scope, Teach Shock Wave over Pound (Slot 3), Use Calcium, Escape Rope out, bike to Dept. Store
Elevator to 5F
Sell Nugget, buy 1 X-Attack, 11 X-Speeds, 34 X-Specials, 4 X-Accuracies, 4 Guard Specs
Leave, Super Repel, toss Moon Stone, heal if very low (but not too high!), fly to Lavender
Lavender Rival: X-Special, Psychic, SW, Psychic, Return, Psychic
If you got Sand, you can X-Acc and get the extra one in a later floor of tower
Get Elixir
Take Heal Pad
Haunter: Psychic
Gastlies: WP x2
Get Rare Candy
Marowak: WP x2
Rocket 1: Return x2, Psychic (Return with decent atk)
Rocket 2: Return x2
Rocket 3: Return x4
Get Pokeflute
Fly to Celadon
Go west and wake up the Snorlax
Get Rare Candy
Get Max Elixir
Do Safari Zone, get Full Restore, Gold Teeth, Surf
Rare Candy x4 to L43 in Super Repel menu in Safari Zone (your cursor is on bird!)
Fly stationary (Fuschia)
Juggler 1: Return x4
Koga: Psychic, Psychic + X-Special + Psychic, Psychic, Psychic
Get Strength from Warden
Teach Surf and Strength to Squirtle, use Super Repel, Max Ether Psychic
Fly to Pallet Town then surf down
Mansion: get Carbos if lower speed, Blizzard and Elixir then Secret Key
Escape rope out
Go to mart, buy 2 Full Heals and max Hypers
Blaine: X-Special x2, Psychic, X-Special x2, X-Speed, (Heal), WP, WP (OHKO Range)
0 Neutral SpAtk -> 10/16 OHKO, x/11+/0+ -> Guaranteed OHKO
0 Neutral Spdef -> RK9 Fire Blast does 79-93
Walk out of the gym
Say NO to Bill
Fly to Celadon
Beauty 1: Return x2
Beauty 2: Return
Erika: Return, Psychic x2
Fly to Saffron
Before Silph Rival, Max Elixir, Carbos if you got it, heal to full.
Silph Rival: X-Speed, X-Special x2, SW, SW, Psychic, SW x2, Psychic
Grunt: Psychic, WP, Return
Gio: X-Special x2, Psychic, Psychic, SW x2, Psychic
Heal if dead to Zam (43-55), Escape Rope out
Sabrina: (X-Speed if slower than Kadabra), Return, Return, Psychic, Return
Always slower than Zam, faster than Kadabra at 16+ IV neutral speed (outsped into Reflect is real bad)
Escape rope out, fly to Viridian and bike to the gym
Black Belt: Psychic, Return, Psychic
Elixir, heal if necessary
Cooltrainer: X-Special, WP, Psychic x4 (WP Marowak if -spatk)
Gio: WP, X-Special, Psychic x4
Can outspeed Dugtrio at 28+ IV plus nature (26+ with carbos)
Before Viridian Rival, heal to full, Super Repel and teach Blizzard over Water Pulse (Slot 3)
Viridian Rival: X-Speed, X-Special x3, SW, Psychic, X-Accuracy, SW, Psychic, Blizzard x2
Standard VR
Box Heal, deposit all slaves, buy max Full Restores
Lorelei: X-Speed, X-Special x2, SW x2, X-Special x3, X-Attack, SW x2, Psychic x2 (Return + SW if riskier Agatha), Return
Can outspeed Jynx at 24+ IV plus nature (or 21+ with carbos)
Heal to full
Bruno: Guard Spec, X-Speed, X-Special x3, Psychic x5
Can outspeed Hitmonlee at 29+ IV plus nature (or 26+ with carbos)
You have a bonus Guard Spec if you need to heal during this setup and it wears off early
It's okay to be low-ish going into this fight (Gengar can only toxic you)
Slightly riskier strat can only be done with reasonable special attack, +1 Gengar is a bad range with -spatk
Agatha (safer): X-Speed (x2 if less than 18 IV Neutral), X-Special x4, SW + SW, SW, Psychic x3
Agatha (riskier): X-Speed, X-Special, Psychic, X-Special x3, (X-Speed again if less than 18 IV Neutral), SW, Psychic x3
Heal if necessary
Lance: X-Speed, X-Accuracy, X-Special x2, SW, Blizzard x4
Skip X-Speed at 21+ IV plus nature (19+ with carbos)
@0 Def Neutral -> Gyara HB 96-113, Aero HB 79-93, Always Slower than Aero
Elixir, heal to full
Champ: Guard Spec, X-Speed (x2 if less than 22 Neutral), X-Special x2, Guard Spec, X-Special x2, X-Accuracy, SW, Blizzard x2, SW, SW x2, Psychic
RK9  @0 def/spdef: Flamethrower 81-96, E-Speed 51-61
_______________________________________________________
Franklin/Flint route changes
Franklin: MK, WP
Flint: WP, MK (MP if decent atk)
Drowzee on Dig Rocket is now a (pretty good) range
MK Pidgeotto on Boat Rival is now a range
MK Ivysaur on Boat Rival is now a way worse range