From most to least significant:
- Skip Plusle Protect + lead Makuhita on Nascour/Evice
- Catch Makuhita and deposit Umbreon for Ferma: https://pastebin.com/3jZ9wmJE
- Moltres burning for better Espeons (Klest, shifted Scizor)
- Lab deathwarp (optimal on ~70% of runs): https://pastebin.com/GLx5RbTe
- Buy 1 Calcium for Typhlosion (2 with 22 IV and 19799+ exp.)
- Skip buying Full Heals
- Faster/riskier Delcatty/Steelix
- Flex X Special on Ston/Nascour
- Buy 35 X Specials post-Quilava (skip all sells, get extra walking cycle; use X Special for Electrike, Vibrava, Remil and Skrub 2)
- More early calls for Quilava
- Faster Lonia (skip X Special)

EXPECTED TIME SAVE: 55 seconds + more appropriate risk for each run
QUALITY OF LIFE: Worse Espeon resets, better Quilava split, better Cail, similar Quilava resets, similar early game, similar late game (overall about the same; worst part of running Colo is high chance of resetting after 19 boring minutes and a successful Espeon manip)