Early game route differences;
- Get TM20 in Game Corner

PALLET TOWN
- Surf south, hug right side
 
CINNABAR ISLAND
- Revive Omanyte and Aerodactyl
- Use a Lure and catch a Koffing
- Stone evolve all required Pokes
- Leave Koffing, Aerodactyl plus anything to evolve in the team
- Grab Rare Candy on 3rd Floor
- Set Aerodactyl as ride poke
- Candy Koffing to 50 and evolve to Weezing
- Teach Dark Pulse to Weezing over Self-destruct
- Scientist Ted: X Spec, SB, DP x3
- Should have 48 Pokes caught before leaving
- Can heal using the beds downstairs
- Pick up Secret Key, Escape Rope out
- Delay Blaine
- Fly to Vermilion
 
VERMILION CITY
- Lt. Surge: DP, DP, SB
- Teach Thunderbolt over Toxic
- Fly to Celadon
 
SAFFRON CITY
- Head to Silph Co.
- Blue: SB, Tbolt x2
- Consider using Aero
- Archer & Grunt: X Spec, Tbolt Muk, Golbat, Weezing, Raticate
- Jessie & James: Tbolt Weezing, X Spec on Weezing on Aero turn, DP + Crunch Arbok
- Giovanni 2: X Spec, SB, DP, DP x2
- Head to Floor 7 and get Lapras
- Head to Floor 10 and get Candy + Flamethrower TM
- Teach Flamethrower over Haze
- Get Porygon at Center
- Shop: 
- Teleport order: BL TR BR BR TR TL TL
- Sabrina: X SpDef x2, X Spec, X Speed x2, SB, DP, FT, Tbolt
- Fly to Celadon
  
CELADON CITY
- Go fight Erika
- Erika: FT x3
- Fly to Fuschia

FUCHSIA CITY
- Ace Trainer Cayden: X Spec, Tbolt x2, FT
- Koga: X Spec x2, X Speed, (DP x2), FT, Tbolt, DP x2
- Get Gold Teeth and deliver them 
- Fly to Cinnabar
 
CINNABAR ISLAND
- Blaine: X SpDef, X Spec x2, X Speed, SB x4

VIRIDIAN CITY
- Unlock the Gym
- Tamer Cole: X Spec, FT, DP
- Ace Trainer Samuel: Ouch EQ hurts
- Blackbelt Takashi: 
- Giovanni:
- Heal to full
- Rival 5: 
 
VICTORY ROAD
- Ace Trainer Naomi:
- Juggler Nelson:
- Free heal from Jenny
- Ace Trainer Caroline: 
- Pokemaniac: 
 
ELITE FOUR
- Lorelei: 
- Bruno: 
- Agatha: 
- Lance: 
- Champ: