Problems with low HP:
- Inefficient HP-to-defenses ratio
- Counter/Mirror Coat
- Poison damage
- Minimum damage moves (SE Arm Thrust, Constrict, etc.)
- Fixed damage moves (Seismic Toss, Night Shade, Dragon Rage, Sonicboom, Psywave)
- Transform
- Harder to use Substitute
- Harder to survive early game if glass cannon defenses

Problems with high HP:
- Leech Seed
- Inefficient healing in late game (not inherently bad, just means your high base HP is wasted)
- Endeavor (not inherently bad, just means your high base HP is wasted)
- Super Fang (not inherently bad, just means your high base HP is wasted)
- Pain Split
- Leech moves (Giga Drain, etc.)